node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
flaD | legI | Cj0887c | Cj1327 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | 0.602 |
flaD | pseA | Cj0887c | Cj1316c | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | Pseudaminic acid biosynthesis PseA protein | 0.577 |
flaD | pseB | Cj0887c | Cj1293 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | UDP-GlcNAc-specific C4,6 dehydratase/C5 epimerase; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.881 |
flaD | pseC | Cj0887c | Cj1294 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | C4 aminotransferase; Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4- hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L- AltNAc | 0.835 |
flaD | pseD | Cj0887c | Cj1333 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | PseD protein | 0.865 |
flaD | pseF | Cj0887c | Cj1311 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | Acylneuraminate cytidylyltransferase; Catalyzes the final step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates the activation of pseudaminic acid with CMP by forming CMP-pseudaminic acid (By similarity) | 0.655 |
flaD | pseG | Cj0887c | Cj1312 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | Nucleotidase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc; Nucleotide sugar hydrolase that catalyzes the fourth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates the removal of UDP from C-1 of UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose forming 2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose | 0.894 |
flaD | pseH | Cj0887c | Cj1313 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | N-acetyltransferase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc; Catalyzes the third step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates N-4 acetylation of UDP-4-amino-4,6-dideoxy- beta-L-AltNAc to form UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose (By similarity) | 0.874 |
flaD | pseI | Cj0887c | Cj1317 | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | Pse synthetase; Catalyzes the fifth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2,4-diacetamido-2,4,6-trideoxy-beta-l-altropyranose, forming pseudaminic acid | 0.715 |
legI | flaD | Cj1327 | Cj0887c | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella | 0.602 |
legI | pseA | Cj1327 | Cj1316c | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | Pseudaminic acid biosynthesis PseA protein | 0.617 |
legI | pseB | Cj1327 | Cj1293 | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | UDP-GlcNAc-specific C4,6 dehydratase/C5 epimerase; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.711 |
legI | pseC | Cj1327 | Cj1294 | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | C4 aminotransferase; Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4- hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L- AltNAc | 0.693 |
legI | pseD | Cj1327 | Cj1333 | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | PseD protein | 0.949 |
legI | pseF | Cj1327 | Cj1311 | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | Acylneuraminate cytidylyltransferase; Catalyzes the final step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates the activation of pseudaminic acid with CMP by forming CMP-pseudaminic acid (By similarity) | 0.993 |
legI | pseG | Cj1327 | Cj1312 | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | Nucleotidase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc; Nucleotide sugar hydrolase that catalyzes the fourth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates the removal of UDP from C-1 of UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose forming 2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose | 0.858 |
legI | pseH | Cj1327 | Cj1313 | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | N-acetyltransferase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc; Catalyzes the third step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates N-4 acetylation of UDP-4-amino-4,6-dideoxy- beta-L-AltNAc to form UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose (By similarity) | 0.721 |
legI | pseI | Cj1327 | Cj1317 | N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7- diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N’-diacetyllegionaminic acid | Pse synthetase; Catalyzes the fifth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2,4-diacetamido-2,4,6-trideoxy-beta-l-altropyranose, forming pseudaminic acid | 0.501 |
neuB1 | pseA | Cj1141 | Cj1316c | Sialic acid synthase | Pseudaminic acid biosynthesis PseA protein | 0.413 |
neuB1 | pseB | Cj1141 | Cj1293 | Sialic acid synthase | UDP-GlcNAc-specific C4,6 dehydratase/C5 epimerase; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.769 |