| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HVO_1348 | agl8 | HVO_1348 | HVO_2060 | Putative yjeF family carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | 0.978 |
| HVO_1348 | folCP | HVO_1348 | HVO_1088 | Putative yjeF family carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase; Can complement an H.volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB | 0.617 |
| HVO_1348 | lsm | HVO_1348 | HVO_2723 | Putative yjeF family carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration | snRNP-like protein | 0.738 |
| HVO_1348 | vacB | HVO_1348 | HVO_0388 | Putative yjeF family carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration | Ribonuclease R | 0.598 |
| agl12 | agl14 | HVO_2059 | HVO_2058 | UDP-glucose 4-epimerase; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | RmlD substrate binding domain superfamily protein; Reductase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | 0.980 |
| agl12 | agl8 | HVO_2059 | HVO_2060 | UDP-glucose 4-epimerase; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | 0.868 |
| agl14 | agl12 | HVO_2058 | HVO_2059 | RmlD substrate binding domain superfamily protein; Reductase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | UDP-glucose 4-epimerase; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | 0.980 |
| agl14 | agl8 | HVO_2058 | HVO_2060 | RmlD substrate binding domain superfamily protein; Reductase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | 0.655 |
| agl8 | HVO_1348 | HVO_2060 | HVO_1348 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | Putative yjeF family carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration | 0.978 |
| agl8 | agl12 | HVO_2060 | HVO_2059 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | UDP-glucose 4-epimerase; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | 0.868 |
| agl8 | agl14 | HVO_2060 | HVO_2058 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | RmlD substrate binding domain superfamily protein; Reductase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier | 0.655 |
| agl8 | folCP | HVO_2060 | HVO_1088 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase; Can complement an H.volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB | 0.721 |
| agl8 | lsm | HVO_2060 | HVO_2723 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | snRNP-like protein | 0.787 |
| agl8 | mtaP | HVO_2060 | HVO_0692 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | Methylthioadenosine phosphorylase | 0.585 |
| agl8 | rfc | HVO_2060 | HVO_0203 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA | 0.634 |
| agl8 | rfcB | HVO_2060 | HVO_2427 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA | 0.634 |
| agl8 | rfcC | HVO_2060 | HVO_0145 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | Replication factor C small subunit | 0.634 |
| agl8 | vacB | HVO_2060 | HVO_0388 | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | Ribonuclease R | 0.843 |
| folCP | HVO_1348 | HVO_1088 | HVO_1348 | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase; Can complement an H.volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB | Putative yjeF family carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration | 0.617 |
| folCP | agl8 | HVO_1088 | HVO_2060 | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase; Can complement an H.volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB | GDP-mannose mannosyl hydrolase; Nudix hydrolase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at ’Asn-532’ of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Mediates attachment of sugar 3 in the tetrasaccharide | 0.721 |
