node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HP_0045 | HP_0646 | HP0045 | HP0646 | Nodulation protein (nolK) | UDP-glucose pyrophosphorylase (galU) | 0.891 |
HP_0045 | pseB | HP0045 | HP0840 | Nodulation protein (nolK) | flaA1 protein; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.896 |
HP_0045 | pseC | HP0045 | HP0366 | Nodulation protein (nolK) | Spore coat polysaccharide biosynthesis protein C; Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4- hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L- AltNAc | 0.898 |
HP_0045 | pseI | HP0045 | HP0178 | Nodulation protein (nolK) | Sialic acid synthase; Catalyzes the fifth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2,4-diacetamido-2,4,6-trideoxy-beta-l-altropyranose, forming pseudaminic acid (By similarity) | 0.453 |
HP_0646 | HP_0045 | HP0646 | HP0045 | UDP-glucose pyrophosphorylase (galU) | Nodulation protein (nolK) | 0.891 |
HP_0646 | HP_0859 | HP0646 | HP0859 | UDP-glucose pyrophosphorylase (galU) | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose | 0.894 |
HP_0646 | glmU | HP0646 | HP0683 | UDP-glucose pyrophosphorylase (galU) | Bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain | 0.874 |
HP_0646 | murA | HP0646 | HP0648 | UDP-glucose pyrophosphorylase (galU) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine | 0.890 |
HP_0646 | pseB | HP0646 | HP0840 | UDP-glucose pyrophosphorylase (galU) | flaA1 protein; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.898 |
HP_0646 | pseH | HP0646 | HP0327 | UDP-glucose pyrophosphorylase (galU) | Flagellar protein FlaG; Catalyzes the third step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates N-4 acetylation of UDP-4-amino-4,6-dideoxy- beta-L-AltNAc to form UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose | 0.444 |
HP_0837 | HP_0841 | HP0837 | HP0841 | Hypothetical protein | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase | 0.802 |
HP_0837 | pseB | HP0837 | HP0840 | Hypothetical protein | flaA1 protein; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.880 |
HP_0837 | pseH | HP0837 | HP0327 | Hypothetical protein | Flagellar protein FlaG; Catalyzes the third step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates N-4 acetylation of UDP-4-amino-4,6-dideoxy- beta-L-AltNAc to form UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L- altropyranose | 0.468 |
HP_0841 | HP_0837 | HP0841 | HP0837 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase | Hypothetical protein | 0.802 |
HP_0841 | glmU | HP0841 | HP0683 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase | Bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain | 0.560 |
HP_0841 | pseB | HP0841 | HP0840 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase | flaA1 protein; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.864 |
HP_0859 | HP_0646 | HP0859 | HP0646 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose | UDP-glucose pyrophosphorylase (galU) | 0.894 |
HP_0859 | pseB | HP0859 | HP0840 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose | flaA1 protein; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy- beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D- xylo-4-hexulose | 0.897 |
HP_0859 | pseC | HP0859 | HP0366 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose | Spore coat polysaccharide biosynthesis protein C; Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4- hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L- AltNAc | 0.891 |
HP_0859 | pseI | HP0859 | HP0178 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose | Sialic acid synthase; Catalyzes the fifth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2,4-diacetamido-2,4,6-trideoxy-beta-l-altropyranose, forming pseudaminic acid (By similarity) | 0.453 |