• Version:
  • 10.5 (archived version)
STRINGSTRING
wbpI wbpI wbpB wbpB wzx wzx wbpE wbpE wbpD wbpD wbpA wbpA wbpJ wbpJ wbpK wbpK hisF2 hisF2 wbpG wbpG wbpH wbpH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
wbpDUDP-2-acetamido-3-amino-23-dideoxy-d-glucuronic acid N-acetyltransferase WbpD; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the transfer of an acetyl group to the C-3 amino position of UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D- glucuronate (UDP-D-GlcNAc3NA) (191 aa)    
Predicted Functional Partners:
wbpE
UDP-2-acetamido-2-dideoxy-d-ribo-hex-3-uluronic acid transaminase WbpE; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the amination of UDP-2-acetamido-2-deoxy-3- oxo-D-glucuronic acid (UDP-3-oxo-D-GlcNAcA) to UDP-2-acetamido-3- amino-2,3-dideoxy-D-glucuronic acid (UDP-GlcNAc3NA), using L- glutamate as the preferred amine donor (359 aa)
 
  0.999
wbpI
UDP-N-acetylglucosamine 2-epimerase; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the epimerization of UDP-2,3-diacetamido- 2,3-dideoxy-alpha-D-glucuronic acid (UDP-alpha-D-GlcNAc3NAcA) to UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid (UDP- alpha-D-ManNAc3NAcA). Exhibits high specificity towards the substrate as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2- acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D- GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates (354 aa)
 
 
  0.998
wbpB
UDP-2-acetamido-2-deoxy-d-glucuronic acid 3-dehydrogenase WbpB; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the NAD-dependent oxidation of UDP-N- acetylglucosaminuronic acid (UDP-D-GlcNAcA) to UDP-2-acetamido-2- deoxy-3-oxo-D-glucuronic acid (UDP-3-oxo-D-GlcNAcA). Can not use UDP-GlcNAc or UDP-GalNAc as the nucleotide sugar substrate, and can use only poorly UDP-D-glucuronic acid (UDP-GlcA). Undergoes an NAD(+) recycling mechanism using 2-oxoglutarate as an oxidant (316 aa)
 
   
  0.993
wzx
O-antigen translocase (411 aa)
 
   
  0.988
wbpA
UDP-N-acetyl-d-glucosamine 6-dehydrogenase; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the C-6 dehydrogenation of UDP-D-GlcNAc to UDP-N-acetylglucosaminuronic acid (UDP-D-GlcNAcA) (436 aa)
 
   
  0.986
wbpH
Glycosyltransferase WbpH (373 aa)
 
   
  0.983
wbpJ
Glycosyl transferase WbpJ (413 aa)
 
   
  0.980
wbpK
NAD-dependent epimerase/dehydratase (316 aa)
   
   
  0.940
wbpG
LPS biosynthesis protein WbpG (377 aa)
 
   
  0.928
hisF2
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) (251 aa)
   
        0.926
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, Micrococcus pyocyaneus, P. aeruginosa, P. aeruginosa PAO1, Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO1, Pseudomonas aeruginosa str. PAO1, Pseudomonas polycolor, Pseudomonas pyocyanea, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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