node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP1083 | MMP1690 | MMP1083 | MMP1690 | Imidazole glycerol phosphate synthase subunit HisF | hisA/hisF family protein | 0.984 |
MMP1083 | hisA | MMP1083 | MMP0417 | Imidazole glycerol phosphate synthase subunit HisF | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | 0.998 |
MMP1083 | hisB | MMP1083 | MMP0548 | Imidazole glycerol phosphate synthase subunit HisF | Imidazoleglycerol-phosphate dehydratase | 0.999 |
MMP1083 | hisD | MMP1083 | MMP0968 | Imidazole glycerol phosphate synthase subunit HisF | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine | 0.998 |
MMP1083 | hisE | MMP1083 | MMP0051 | Imidazole glycerol phosphate synthase subunit HisF | phosphoribosyl-ATP pyrophosphatase | 0.986 |
MMP1083 | hisF | MMP1083 | MMP1722 | Imidazole glycerol phosphate synthase subunit HisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit | 0.817 |
MMP1083 | hisG | MMP1083 | MMP0947 | Imidazole glycerol phosphate synthase subunit HisF | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity | 0.998 |
MMP1083 | hisH2 | MMP1083 | MMP1082 | Imidazole glycerol phosphate synthase subunit HisF | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) | 0.999 |
MMP1083 | hisI | MMP1083 | MMP0280 | Imidazole glycerol phosphate synthase subunit HisF | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP | 0.996 |
MMP1083 | wbpG | MMP1083 | MMP1081 | Imidazole glycerol phosphate synthase subunit HisF | LPS biosynthesis protein WbpG | 0.983 |
MMP1690 | MMP1083 | MMP1690 | MMP1083 | hisA/hisF family protein | Imidazole glycerol phosphate synthase subunit HisF | 0.984 |
MMP1690 | hisA | MMP1690 | MMP0417 | hisA/hisF family protein | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | 0.839 |
MMP1690 | hisF | MMP1690 | MMP1722 | hisA/hisF family protein | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit | 0.988 |
MMP1690 | hisH2 | MMP1690 | MMP1082 | hisA/hisF family protein | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) | 0.985 |
MMP1690 | hisI | MMP1690 | MMP0280 | hisA/hisF family protein | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP | 0.987 |
hisA | MMP1083 | MMP0417 | MMP1083 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | Imidazole glycerol phosphate synthase subunit HisF | 0.998 |
hisA | MMP1690 | MMP0417 | MMP1690 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | hisA/hisF family protein | 0.839 |
hisA | hisB | MMP0417 | MMP0548 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | Imidazoleglycerol-phosphate dehydratase | 0.974 |
hisA | hisD | MMP0417 | MMP0968 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine | 0.970 |
hisA | hisE | MMP0417 | MMP0051 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | phosphoribosyl-ATP pyrophosphatase | 0.980 |