PAU_02230 protein (Photorhabdus asymbiotica)

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PAU_02230

Insecticidal toxin; Toxin that acts on host cells by modifying Rho proteins by tyrosine GlcNAcylation and heterotrimeric G alpha proteins by deamidation. Catalyzes the mono-O-GlcNAcylation of small GTPases of the Rho family (RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42) in eukaryotic host cells at the conserved tyrosine residue located in the switch I region (Tyr-32/34), using UDP-N-acetylglucosamine (UDP-GlcNAc) as the sugar donor; other GTPases of the Rho, Ras or Rab families are not substrates. Tyrosine glycosylation inhibits Rho activation and prevents interaction with downstream effe [...] (2957 aa)

Predicted Functional Partners:

PAU_02231

0.528

PAU_02232

0.478

PAU_02233

0.433

Your Current Organism:

Photorhabdus asymbiotica

NCBI taxonomy Id: 553480
Other names: P. asymbiotica, P. asymbiotica subsp. asymbiotica, P. asymbiotica subsp. asymbiotica ATCC 43949, Photorhabdus asymbiotica, Photorhabdus asymbiotica subsp. asymbiotica, Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949, Photorhabdus asymbiotica subsp. asymbiotica str. ATCC 43949, Photorhabdus asymbiotica subsp. asymbiotica strain ATCC 43949

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
PAU_02230	PAU_02231	Insecticidal toxin; Toxin that acts on host cells by modifying Rho proteins by tyrosine GlcNAcylation and heterotrimeric G alpha proteins by deamidation. Catalyzes the mono-O-GlcNAcylation of small GTPases of the Rho family (RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42) in eukaryotic host cells at the conserved tyrosine residue located in the switch I region (Tyr-32/34), using UDP-N-acetylglucosamine (UDP-GlcNAc) as the sugar donor; other GTPases of the Rho, Ras or Rab families are not substrates. Tyrosine glycosylation inhibits Rho activation and prevents interaction with downstream effe [...]	Hypothetical protein	0.528
PAU_02230	PAU_02232	Insecticidal toxin; Toxin that acts on host cells by modifying Rho proteins by tyrosine GlcNAcylation and heterotrimeric G alpha proteins by deamidation. Catalyzes the mono-O-GlcNAcylation of small GTPases of the Rho family (RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42) in eukaryotic host cells at the conserved tyrosine residue located in the switch I region (Tyr-32/34), using UDP-N-acetylglucosamine (UDP-GlcNAc) as the sugar donor; other GTPases of the Rho, Ras or Rab families are not substrates. Tyrosine glycosylation inhibits Rho activation and prevents interaction with downstream effe [...]	Hypothetical protein	0.478
PAU_02230	PAU_02233	Insecticidal toxin; Toxin that acts on host cells by modifying Rho proteins by tyrosine GlcNAcylation and heterotrimeric G alpha proteins by deamidation. Catalyzes the mono-O-GlcNAcylation of small GTPases of the Rho family (RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42) in eukaryotic host cells at the conserved tyrosine residue located in the switch I region (Tyr-32/34), using UDP-N-acetylglucosamine (UDP-GlcNAc) as the sugar donor; other GTPases of the Rho, Ras or Rab families are not substrates. Tyrosine glycosylation inhibits Rho activation and prevents interaction with downstream effe [...]	Hypothetical protein	0.433
PAU_02231	PAU_02230	Hypothetical protein	Insecticidal toxin; Toxin that acts on host cells by modifying Rho proteins by tyrosine GlcNAcylation and heterotrimeric G alpha proteins by deamidation. Catalyzes the mono-O-GlcNAcylation of small GTPases of the Rho family (RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42) in eukaryotic host cells at the conserved tyrosine residue located in the switch I region (Tyr-32/34), using UDP-N-acetylglucosamine (UDP-GlcNAc) as the sugar donor; other GTPases of the Rho, Ras or Rab families are not substrates. Tyrosine glycosylation inhibits Rho activation and prevents interaction with downstream effe [...]	0.528
PAU_02231	PAU_02232	Hypothetical protein	Hypothetical protein	0.767
PAU_02231	PAU_02233	Hypothetical protein	Hypothetical protein	0.685
PAU_02232	PAU_02230	Hypothetical protein	Insecticidal toxin; Toxin that acts on host cells by modifying Rho proteins by tyrosine GlcNAcylation and heterotrimeric G alpha proteins by deamidation. Catalyzes the mono-O-GlcNAcylation of small GTPases of the Rho family (RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42) in eukaryotic host cells at the conserved tyrosine residue located in the switch I region (Tyr-32/34), using UDP-N-acetylglucosamine (UDP-GlcNAc) as the sugar donor; other GTPases of the Rho, Ras or Rab families are not substrates. Tyrosine glycosylation inhibits Rho activation and prevents interaction with downstream effe [...]	0.478
PAU_02232	PAU_02231	Hypothetical protein	Hypothetical protein	0.767
PAU_02232	PAU_02233	Hypothetical protein	Hypothetical protein	0.928
PAU_02233	PAU_02230	Hypothetical protein	Insecticidal toxin; Toxin that acts on host cells by modifying Rho proteins by tyrosine GlcNAcylation and heterotrimeric G alpha proteins by deamidation. Catalyzes the mono-O-GlcNAcylation of small GTPases of the Rho family (RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42) in eukaryotic host cells at the conserved tyrosine residue located in the switch I region (Tyr-32/34), using UDP-N-acetylglucosamine (UDP-GlcNAc) as the sugar donor; other GTPases of the Rho, Ras or Rab families are not substrates. Tyrosine glycosylation inhibits Rho activation and prevents interaction with downstream effe [...]	0.433
PAU_02233	PAU_02231	Hypothetical protein	Hypothetical protein	0.685
PAU_02233	PAU_02232	Hypothetical protein	Hypothetical protein	0.928

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