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  • 10.5 (archived version)
STRINGSTRING

Database Knowledge

Relevant datasets in Homo sapiens:

annotated pathway (KEGG)
Name: Cardiac muscle contraction
 MT-CYB  
 CYC1  
 UQCRFS1  
 MT-CO2  
 MT-CO3  
 MT-CO1  
 UQCRB  
 UQCRC2  
 UQCRQ   [... and 66 other proteins]
curated pathway
Catalysis
 MT-CYB  
 CYC1  
 UQCRFS1  
 UQCRB  
 CYCS  
 UQCRC2  
 UQCRQ   [... and 3 other proteins]
curated complex (Gene Ontology)
cytochrome complex
 MT-CYB  
 UQCRFS1  
 MT-CO2  
 MT-CO3  
 MT-CO1  
 UQCRB  
 UQCRC2   [... and 17 other proteins]
curated pathway
Complex: Complex III
 MT-CYB  
 CYC1  
 UQCRFS1  
 UQCRB  
 UQCRC2  
 UQCRQ   [... and 3 other proteins]
curated pathway
Catalysis
 MT-CO2  
 MT-CO3  
 MT-CO1  
 CYCS   [... and 11 other proteins]
curated complex (Gene Ontology)
mitochondrial respiratory chain complex III
 MT-CYB  
 UQCRFS1  
 UQCRB  
 UQCRC2   [... and 4 other proteins]
curated complex (Gene Ontology)
respiratory chain complex III
 MT-CYB  
 UQCRFS1  
 UQCRB  
 UQCRC2   [... and 4 other proteins]
curated pathway
Complex: Complex IV
 MT-CO2  
 MT-CO3  
 MT-CO1   [... and 11 other proteins]
curated complex (Gene Ontology)
respiratory chain complex IV
 MT-CO2  
 MT-CO3  
 MT-CO1   [... and 10 other proteins]
annotated pathway (KEGG)
Name: Parkinson's disease
 MT-CYB  
 CYC1  
 UQCRFS1  
 MT-CO2  
 MT-CO3  
 MT-CO1  
 UQCRB  
 CYCS  
 MT-ND4  
 UQCRC2  
 UQCRQ   [... and 127 other proteins]
[truncated after 10 items]

Relevant information transferred from other organisms:

curated complex (Gene Ontology)
mitochondrial respiratory chain complex IV
Drosophila melanogaster: 
 mt:CoII  
 mt:CoIII  
 mt:CoI   [... and 14 other proteins]
curated pathway
Catalysis
Sus scrofa: 
 ENSSSCG00000029622  
 ENSSSCG00000020682  
 UQCRFS1  
 CYCS  
 ENSSSCG00000017811  
 ENSSSCG00000025388  
 ENSSSCG00000024275  
 ENSSSCG00000007843  
 ENSSSCG00000007845  
 UQCRQ   [... and 5 other proteins]
curated pathway
Catalysis
Drosophila melanogaster: 
 mt:Cyt-b  
 CG4769  
 CG14508  
 CG17856  
 CG3560  
 Cyt-c-p  
 CG3731  
 CG4169  
 CG7580   [... and 3 other proteins]
curated pathway
Pathway: aerobic respiration (linear view)
Saccharomyces cerevisiae: 
 COB  
 CYT1  
 RIP1  
 COX2  
 COX3  
 COX1  
 QCR7  
 QCR2  
 QCR8   [... and 31 other proteins]
curated pathway
Pathway: aerobic respiration (cytochrome c)
Saccharomyces cerevisiae: 
 COB  
 CYT1  
 RIP1  
 COX2  
 COX3  
 COX1  
 QCR7  
 QCR2  
 QCR8   [... and 31 other proteins]
curated pathway
Pathway: aerobic respiration -- electron donor II
Mus musculus: 
 mt-Cytb  
 Cyc1  
 Uqcrfs1  
 mt-Co2  
 mt-Co3  
 mt-Co1  
 Uqcrb  
 Uqcrc2  
 Uqcrq   [... and 61 other proteins]
curated pathway
Complex: Ubiquinol-cytochrome c reductase (name copied from entity in Homo sapiens)
Drosophila melanogaster: 
 mt:Cyt-b  
 CG4769  
 CG14508  
 CG17856  
 CG3560  
 CG3731  
 CG4169  
 CG7580   [... and 3 other proteins]
curated pathway
Catalysis
Bos taurus: 
 CYTB  
 CYC1  
 UQCRFS1  
 UQCRB  
 100851009  
 CYC  
 UQCRC2  
 UQCRQ   [... and 4 other proteins]
curated pathway
Catalysis
Rattus norvegicus: 
 CYTB  
 Cyc1  
 Uqcrfs1  
 LOC690675  
 RGD1562558  
 Uqcrc1  
 Uqcrc2  
 Uqcrq   [... and 4 other proteins]
curated pathway
Catalysis
Danio rerio: 
 CYTB  
 cyc1  
 uqcrb  
 cycs  
 uqcrc2a  
 uqcrc2b  
 uqcrq   [... and 2 other proteins]
[truncated after 10 items]
Functional enrichments in your set of proteinsNote: some enrichments may be expected here (why?)
Biological Process (GO)
pathway ID
pathway description
count in gene set
false discovery rate
GO:0022904
respiratory electron transport chain
24
1.23e-44
GO:0045333
cellular respiration
23
8.95e-39
GO:0042775
mitochondrial ATP synthesis coupled electron transport
18
1.19e-35
GO:0006119
oxidative phosphorylation
17
4.23e-32
GO:0046034
ATP metabolic process
19
6.21e-30
(more ...)
 
 
 
 
Molecular Function (GO)
pathway ID
pathway description
count in gene set
false discovery rate
GO:0016491
oxidoreductase activity
22
3.29e-23
GO:0008137
NADH dehydrogenase (ubiquinone) activity
11
3.74e-19
GO:0015078
hydrogen ion transmembrane transporter activity
12
5.03e-18
GO:0008121
ubiquinol-cytochrome-c reductase activity
6
8.32e-14
GO:0009055
electron carrier activity
10
8.32e-14
(more ...)
 
 
 
 
Cellular Component (GO)
pathway ID
pathway description
count in gene set
false discovery rate
GO:0070469
respiratory chain
21
1.47e-41
GO:0098803
respiratory chain complex
19
1.5e-38
GO:0098800
inner mitochondrial membrane protein complex
20
7.05e-38
GO:0005746
mitochondrial respiratory chain
17
1.61e-32
GO:0044455
mitochondrial membrane part
19
7.56e-31
(more ...)
 
 
 
 
KEGG Pathways
pathway ID
pathway description
count in gene set
false discovery rate
05012
Parkinson s disease
30
2.85e-63
00190
Oxidative phosphorylation
27
1.19e-54
05010
Alzheimer s disease
24
2.06e-43
05016
Huntington s disease
24
1.95e-42
04932
Non-alcoholic fatty liver disease (NAFLD)
20
1.6e-34
(more ...)
 
 
 
 
PFAM Protein Domains
pathway ID
pathway description
count in gene set
false discovery rate
PF00361
NADH-Ubiquinone/plastoquinone (complex I), various chains
3
9.42e-06
 
 
 
 
INTERPRO Protein Domains and Features
pathway ID
pathway description
count in gene set
false discovery rate
IPR001750
NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
3
2.01e-05
 
 
 
 
Statistical background
For the above enrichment analysis,
the following statistical background
is assumed:
Save / Export
Biological Process (GO)
25 GO-terms significantly enriched; file-format: tab-delimited
Molecular Function (GO)
13 GO-terms significantly enriched; file-format: tab-delimited
Cellular Component (GO)
25 GO-terms significantly enriched; file-format: tab-delimited
KEGG Pathways
14 pathways significantly enriched; file-format: tab-delimited
PFAM Protein Domains
one single domain is enriched; file-format: tab-delimited
INTERPRO Protein Domains and Features
one single domain is enriched; file-format: tab-delimited
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